Testosterone Products Summary

Intramuscular (IM) Injections

Brand names: Primoteston – Depot250®, Sustanon 250®
Product: Injection (deep intramuscular)
Dose: approximately 250 mg every 2 weeks to 3 weeks

Advantages

  • Cheapest form of treatment;
  • Widely available;
  • Primoteston – Depot250® available on the PBS to legal males;
  • Sustanon 250® made up of four esters providing a longer-acting, slow release form of testosterone;
  • Suits most clinical situations for many men requiring treatment;
  • Released slowly and a very effective way of keeping a healthy level of testosterone in your body;
  • Usually ensures the maximum change is effected;
  • The liver does not process testosterone received via intramuscular injection and this acts to minimise any liver damage. Injections can be useful if you have had liver damage in the past;
  • If you do not inject your own hormones, you will need to make fortnightly or three-weekly visits to your doctor. This can be a useful way to ensure you get regular medical access for blood tests, general health, and the best possible maintenance of your health over this time;
  • If you learn to inject your own testosterone, remember to never share needles or syringes. Have an safe,effective disposal container for your needles.

Disadvantages

  • Injections can be painful or uncomfortable for some people. Changing the needle size before injecting can help to overcome this discomfort;
  • Can be difficult to self-inject;
  • Contraindicated for those who have bleeding disorders;
  • Sometimes produces wide mood or energy swings, as blood testosterone level fluctuates rapidly;
  • If you do not inject your own hormones, you will need to make fortnightly visits to your doctor and you may feel more dependent on their services.

Long-lasting Intramuscular (IM) Injection

Brand names: Reandron 1000®
Product: Injection (deep intramuscular)
Dose: approximately 1000mg every 12 weeks (3 months)

Advantages

  • Widely available;
  • Suits most clinical situations for many men requiring treatment;
  • Released slowly and a very effective way of keeping a healthy level of testosterone in your body;
  • Usually ensures the maximum change is effected;
  • Provides long-lasting testosterone levels (about 12 weeks from a single injection). The testosterone is released slowly so that men do not experience the peaks and troughs that are common with standard injections.
  • The liver does not process testosterone received via intramuscular injection and this acts to minimise any liver damage. Injections can be useful if you have had liver damage in the past;
  • If you do not inject your own hormones, you will need to visit to your doctor every three months;
  • Due to the large volume of the injection, some men prefer to spread the injection over several sites (two or more). Most doctors will give this injection in the office and this is a useful way to ensure you get regular medical access for blood tests, general health, and the best possible maintenance of your health over this time;
  • If you learn to inject your own testosterone, remember to never share needles or syringes. Have an safe,effective disposal container for your needles.

Disadvantages

  • Injections can be painful or uncomfortable for some people;
  • Can be difficult to self-inject;
  • Contraindicated in those who have bleeding disorders;
  • If you do not inject your own hormones, you will need to visit your doctor every three months and you may feel more dependent on their services.

Tablets/Capsules

Brand name: Andriol Testocaps®
Dose: 160–240mg in 2–3 divided doses daily

Advantages

  • Andriol (in Australia) is the only safe oral (by mouth) androgen;
  • Oral androgens (tablets) are suitable in the case of bleeding disorders;
  • Tablets are a painless form of delivery.

Disadvantages

  • Tablets require frequent administration (2-3 times daily);
  • Tablets will maintain your testosterone at a safe and effective level only if you take them completely regularly – same time every day without fail;
  • Tablets have an erratic absorption, metabolism and distribution rate;
  • Tablets can be very hard on your liver and can cause extra problems through this form of absorption. This method has caused high blood pressure for many individuals, as well as liver complications such as tumors;
  • Tablets remain in your body for only a very short period of time and is passed from your body in urine within a matter of hours;
  • Some individuals develop gastrointestinal intolerance;
  • Andriol does not suppress menstruation in 50% of men (identified female at birth);
  • Tablets often prove to be too weak for the induction of masculinisation in men (identified female at birth);
  • It may be inconvenient to have hormone tablets in your home where they might present unwanted questions from relatives or friends.
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Gel

Brand name: Testogel® or AndroForte® Cream
Product: Gel (1%) or Cream (5%)
Dose: daily application

Advantages

  • Convenience;
  • Suitable for men who have had full hysterectomy or removal of the ovaries and only require a maintenance dose;
  • Can maintain an effective continuous level of testosterone;
  • Suitable in the case of bleeding disorders.

Disadvantages

  • Gel has been known to be transferred through close skin to skin contact with female partners, causing unwanted effects;
  • Efficacy of cream not yet established.

Patches

Brand names: Androderm®
Product: Testosterone patch

Advantages

  • Suitable for men who have had full hysterectomy or removal of the ovaries and only require a maintenance dose;
  • This method can deliver a continuous steady dose of the hormone;
  • Suitable in the case of bleeding disorders;
  • Convenience.

Disadvantages

  • Patches tend to cause a high rate of skin irritation due to absorption enhancers;
  • Patches deliver very low levels of testosterone and is usually insufficient to effect an acceptable masculine transition for most men in the early years of transition (<3-5 years).

Creme

Brand names: AndroForte®
Product: Testosterone creme

Advantages

  • Suitable for men who have had full hysterectomy or removal of the ovaries and only require a maintenance dose;
  • This method can deliver a continuous steady dose of the hormone;
  • Suitable in the case of bleeding disorders;
  • Convenience.

Disadvantages

  • It appears this preparation is only available in Western Australia.
  • Creme delivers a very low levels of testosterone and is usually insufficient to effect an acceptable masculine transition for most men in the early years of transition (<3-5 years).